Abstract
BackgroundCharacteristics of laboratory findings of COVID-19 patients are of great significance for diagnosis and treatment. Studies that have analysed the variations in hepatic profile in correlation with the inflammatory markers...
Highlights
In December 2019, an infectious severe acute respiratory syndrome was reported in China, found to be caused by a coronavirus.[1]
A recent study found the binding of SARS-CoV-2 virus to ACE 2 (ACE2) on cholangiocytes leading to its dysfunction, which may result in liver injury through inducing a systemic inflammatory response.[13]
Moderate microvesicular steatosis, mild lobular and portal activity found in the liver biopsy specimens of a dead COVID-19 patient indicated the involvement of SARS-CoV-2 in liver damage.[18]
Summary
In December 2019, an infectious severe acute respiratory syndrome was reported in China, found to be caused by a coronavirus.[1]. Other organ dysfunctions, including gastrointestinal symptoms,[7] abnormal liver functions,[8] lymphadenopathy[9] and splenic atrophy, have been observed in patients. These occurrences reflect widespread immunopathology or extrapulmonary dissemination and replication of SARS-coronavirus (CoV).[10] Partial autopsies indicate multiple organ infection by the virus.[11] The pathological changes can be attributed either to the direct cytotoxic effect by local replication of the virus or indirectly due to immune response induced by the viral infection. Studies that have analysed the variations in hepatic profile in correlation with the inflammatory markers in SARS-CoV-2 are limited
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