Abstract
ABSTRACT.Between April and July 2020, and, therefore, prior to the broad recommendation of corticosteroids for severe COVID-19, a total of 50 full autopsies were performed in Manaus. We confirmed two invasive cases of aspergillosis through histopathology and gene sequencing (4%) in our autopsy series. The confirmed invasive aspergillosis incidence seems much lower than expected based on the “probable and possible” definitions, and an individualized approach should be considered for each country scenario. Interestingly, a prolonged length of stay in the intensive care unit was not observed in any of the cases. Timely diagnosis and treatment of fungal infection can reduce mortality rates.
Highlights
The attempt to estimate the frequency of invasive mold disease (IMD) using the gold standard method showed an IMD worldwide average of 2%, with a predominance of COVID-19-associated pulmonary aspergillosis (CAPA), in a systematic review of autopsies performed in COVID-19 deceased patients.[3]
In Manaus, one of the first Brazilian capitals to experience the health system collapse triggered by the first wave of COVID-19, in April 2020, a series of complete diagnostic autopsies were performed in a referral unit
Of the 50 autopsies, one COVID-19 patient identified with Aspergillus penicillioides was reported elsewhere[6]
Summary
The attempt to estimate the frequency of IMD using the gold standard method (i.e., postmortem examination) showed an IMD worldwide average of 2%, with a predominance of COVID-19-associated pulmonary aspergillosis (CAPA), in a systematic review of autopsies performed in COVID-19 deceased patients.[3]. Of the 50 autopsies, one COVID-19 patient identified with Aspergillus penicillioides was reported elsewhere[6] (case 1).
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: The American Journal of Tropical Medicine and Hygiene
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
