Abstract
The new coronavirus disease (COVID-19) is a viral respiratory infection accompanied by systemic endotheliitis. COVID-19 patients usually encounter changes related to hypercoagulability, hypofibrinolysis, and increased intravascular platelet aggregation. There is also a vascular wall thromboresistance decrease and impaired vasomotor function, which significantly increase the risk of thromboembolic complications. Currently, pathogenic aspects of the relationship between COVID-19 and vascular and inflammatory conditions of the optic nerve and retina are actively investigated. One of the triggers of impaired blood flow in ocular vessels may be a perfusion pressure decrease, observed in the acute period of the infectious process. This is related to both COVID-19 clinical course features and to resuscitation specificity as well. Secondary autoimmune inflammation is being considered as a mechanism of damage to the vascular wall in the post-infectious period. In this publication, possible pathogenic links of these diseases are considered for the first time in a specific context of the example of ischemic optic neuropathy associated with coronavirus infection.
Highlights
COVID-19 as a new risk factor for the development of acute vascular diseases of the optic nerve and retina
The new coronavirus disease (COVID-19) is a viral respiratory infection accompanied by systemic “endotheliitis”
COVID-19 patients usually encounter changes related to hypercoagulability, hypofibrinolysis, and increased intravascular platelet aggregation
Summary
One of the triggers of impaired blood flow in ocular vessels may be a perfusion pressure decrease, observed in the acute period of the infectious process This is related to both COVID-19 clinical course features and to resuscitation specificity as well. To cite this article: Turgel VA, Antonov VA, Tultseva SN, Shadrichev FE, Grigorieva NN. COVID-19 as a new risk factor for the development of acute vascular diseases of the optic nerve and retina. Впоследствии это заболевание получило название новой коронавирусной инфекции COVID-19 (COronaVIrus Disease 2019). Роль так называемого синдрома Вальсальвы, возникающего при проведении вентиляции лёгких в положении лёжа на животе, в настоящее время широко обсуждается как главная причина повышения венозного и глазного давления у пациентов с COVID-19 [23].
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