COVID-19 and the kidney; mechanisms of tubular injury by SARS-CoV-2

Rojin Chegini,Saniya Niazi,Hamid Nasri,Bhaskar Vks Lakkakula,Zahra Mojtahedi,Aiyoub Pezeshgi

doi:10.34172/jrip.2021.08

Abstract

Coronavirus disease 2019 (COVID-19) is an ongoing pandemic, reported to cause asymptomatic to severe disease and eventually death. Multi-organ failure and death in patients with severe COVID-19 is associated with increased release of pro-inflammatory cytokines into the blood stream. Renal impairment is reported in a significant proportion of COVID-19 patients and is associated with high mortality. Acute kidney injury (AKI) is multifactorial and involving overlapping pathogenic mechanisms. This review updates the reader of recent publications dealing with the mechanisms underlying AKI in patients with COVID-19. A full understanding of all the possible ways in which the system plays its role in AKI is still a matter of research. Further studies are warranted to better understand the causes of AKI in COVID-19 patients.

Highlights

The disease caused by a SARS-CoV-2 infection, which is called coronavirus disease 2019 (COVID-19), is an ongoing pandemic
Acute kidney injury (AKI) is strongly correlated with the occurrence of respiratory failure disease severity
As AKI is multifactorial involving with overlapping pathogenic mechanisms, this review updates the reader of recent publications dealing with the mechanisms underlying AKI in patients with COVID-19 [8]

Summary

ARTICLE INFO

Article History: Received: 7 September 2020 Accepted: October 2020 ePublished: November 2020. Coronavirus disease 2019 (COVID-19) is an ongoing pandemic, reported to cause asymptomatic to severe disease and eventually death. Multi-organ failure and death in patients with severe COVID-19 is associated with increased release of pro-inflammatory cytokines into the blood stream. Renal impairment is reported in a significant proportion of COVID-19 patients and is associated with high mortality. Acute kidney injury (AKI) is multifactorial and involving overlapping pathogenic mechanisms. This review updates the reader of recent publications dealing with the mechanisms underlying AKI in patients with COVID-19. Further studies are warranted to better understand the causes of AKI in COVID-19 patients. Implication for health policy/practice/research/medical education: Acute kidney injury (AKI) is more common in severely ill patients with COVID-19. Acute kidney injury in COVID-19 patients conferred a poor prognosis and outcomes. COVID-19 and the kidney; mechanisms of tubular injury by SARS-CoV-2.

Introduction

Renal impairment is also reported in a significant

Methods

Findings

Conclusion