Abstract

Abstract The coronavirus disease 2019 (COVID-19), which is caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), was first reported in December, 2019, in Wuhan, China. Even the public health sector experts could not anticipate that the virus would spread rapidly to create the worst worldwide crisis in more than a century. The World Health Organization (WHO) declared COVID-19 a public health emergency on January 30, 2020, but it was not until March 11, 2020 that the WHO declared it a global pandemic. The epidemiology of SARS-CoV-2 is different from the SARS coronavirus outbreak in 2002 and the Middle East Respiratory Syndrome (MERS) in 2012; therefore, neither SARS nor MERS could be used as a suitable model for foreseeing the future of the current pandemic. The influenza pandemic of 1918 could be referred to in order to understand and control the COVID-19 pandemic. Although influenza and the SARS-CoV-2 are from different families of viruses, they are similar in that both silently attacked the world and the societal and political responses to both pandemics have been very much alike. Previously, the 1918 influenza pandemic and unpredictability of the second wave caused distress among people as the first wave of that outbreak (so-called Spanish flu) proved to be relatively mild compared to a much worse second wave, followed by smaller waves. As of April, 2021, the second wave of COVID-19 has occurred around the globe, and future waves may also be expected, if the total population of the world is not vaccinated. This article aims to highlight the key similarities and differences in both pandemics. Similarly, lessons from the previous pan-demics and various possibilities for the future course of COVID-19 are also highlighted.

Highlights

  • In the 21st century, emerging viral infections are among the greatest challenges in the public health sector [1]

  • Since more waves of COVID-19 are expected based on the previous influenza pandemic, we are highlighting a few aspects of both pandemics

  • There was no vaccine for the 1918 influenza virus; several vaccines approved by the Food and Drug Administration (FDA) are available for COVID-19

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Summary

Introduction

In the 21st century, emerging viral infections are among the greatest challenges in the public health sector [1] Among these are zoonotic viruses, which jump to humans from other mammals. Like the SARS outbreak in 2002 and MERS in 2012, SARS-CoV-2 is another coronavirus that emerged in the human population causing severe respiratory disease [4]. The six coronavirus species that infect humans are HKU1, NL63, OC43, 2293, SARS-CoV and MERS-CoV [7]. Further exploration of the epidemiological characteristics of COVID-19 is critical for developing and implementing effective control strategies Both SARS and MERS infect the human population, but in different ways. By highlighting the key differences and similarities in the epidemiology of the influenza and coronavirus pandemics, we can envision various possibilities for the future course of COVID19. Since more waves of COVID-19 are expected based on the previous influenza pandemic, we are highlighting a few aspects of both pandemics

Origin of influenza in 1918 and COVID-19
Biological comparison of the 1918 influenza and COVID-19
Demographical comparison of the 1918 influenza and COVID-19
Phase 1
Phase 2
Phase 3
Pathogenesis of the 1918 influenza in reconstructed 1918 virus
Epidemiologic similarities and differences between the 1918 flu and COVID-19
Findings
Conclusion
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