Abstract
It is suggested that the non-toxic dipeptide carnosine (beta-alanyl-L-histidine) should be examined as a potential protective agent against COVID-19 infection and inflammatory consequences especially in the elderly. Carnosine is an effective anti-inflammatory agent which can also inhibit CD26 and ACE2 activity. It is also suggested that nasal administration would direct the peptide directly to the lungs and escape the attention of serum carnosinase.
Highlights
It is suggested that the non-toxic dipeptide carnosine should be examined as a potential protective agent against COVID-19 infection and inflammatory consequences especially in the elderly
Recent studies have shown that carnosine and acetylcarnosine are present in human blood; carnosine is present in erythrocytes and acetyl-carnosine is mostly in serum; erythrocytes normally contain carnosine and 10-fold less acetyl-carnosine, while the situation is reversed in serum where acetyl-carnosine is the predominant form
These levels decline in elderly humans [38] and low levels of acetyl-carnosine are associated with enhanced frailty [39]
Summary
Another role for carnosine could include beneficial effects in blood. Recent findings suggest that COVID-19 infection can promote in some patients a hypercoagulatory state, which is associated increased mortality [34]. Recent studies have shown that carnosine and acetylcarnosine are present in human blood; carnosine is present in erythrocytes and acetyl-carnosine is mostly in serum; erythrocytes normally contain carnosine and 10-fold less acetyl-carnosine, while the situation is reversed in serum where acetyl-carnosine is the predominant form These levels decline in elderly humans [38] and low levels of acetyl-carnosine are associated with enhanced frailty [39]. Erythrocytes from schizophrenics show evidence of increased aging-related protein glycation [44], while dietary carnosine supplementation has been shown to produce beneficial effects in schizophrenics [45], possibly due, in part, to carnosine’s anti-glycating activity [11,12]
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
