Abstract
BackgroundThe coronavirus disease 2019 pandemic is predicted to have a net negative effect on tuberculosis control, with an estimated excess of 6.3 million tuberculosis cases and 1.4 million deaths by 2025. Programmatic issues such as the lockdown of tuberculosis services affect all patients, while biosocial factors have a differential impact on an individual’s risk for tuberculosis or adverse tuberculosis outcomes.Case presentationWe report three Hispanic cases of incident tuberculosis (two males, 43 and 44 years old; one female, 49 years old) after resolution of coronavirus disease episodes. Coincidentally, all cases shared a common risk factor: a chronic history poorly controlled diabetes.ConclusionsOur findings alert to the threat posed by the synergy between coronavirus disease and diabetes, on tuberculosis reactivation. In medium- to high-risk settings for tuberculosis, we recommend implementation of routine screening for latent tuberculosis infection in these cases, and preventive tuberculosis treatment in those who are positive.
Highlights
The coronavirus disease 2019 pandemic is predicted to have a net negative effect on tuberculosis con‐ trol, with an estimated excess of 6.3 million tuberculosis cases and 1.4 million deaths by 2025
Our findings alert to the threat posed by the synergy between coronavirus disease and diabetes, on tuberculosis reactivation
We cannot ascertain whether these were cases of primary progressive TB disease or of an incipient TB that was smoldering at the time of the COVID-19 diagnosis, or if this was a reactivation of a latent M. tuberculosis infection prompted by the COVID-19 episode
Summary
Our findings alert to the threat posed by the synergy between coronavirus disease and diabetes, on tuberculosis reactivation.
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