Abstract
The coronavirus disease 2019 (COVID-19) is a viral disease caused by a novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that affects the respiratory system of infected individuals. COVID-19 spreads between humans through respiratory droplets produced when an infected person coughs or sneezes. The COVID-19 outbreak originated in Wuhan, China at the end of 2019. As of 29 Sept 2020, over 235 countries, areas or territories across the globe reported a total of 33,441,919 confirmed cases, and 1,003,497 confirmed deaths due to COVID-19. Individuals of all ages are at risk for infection, but in most cases disease severity is associated with age and pre-existing diseases that compromise immunity, like cancer. Numerous reports suggest that people with cancer can be at higher risk of severe illness and related deaths from COVID-19. Therefore, managing cancer care under this pandemic is challenging and requires a collaborative multidisciplinary approach for optimal care of cancer patients in hospital settings. In this comprehensive review, we discuss the impact of the COVID-19 pandemic on cancer patients, their care, and treatment. Further, this review covers the SARS-CoV-2 pandemic, genome characterization, COVID-19 pathophysiology, and associated signaling pathways in cancer, and the choice of anticancer agents as repurposed drugs for treating COVID-19. <br><b>Original article:</b> Pathania AS, Prathipati P, Abdul BAA, et al. COVID-19 and Cancer Comorbidity: Therapeutic Opportunities and Challenges. Theranostics. 2021;11(2):731-753. DOI: 10.7150/thno.51471. <br><i>The article was translated into Russian and published under the terms of the Creative Commons Attribution 4.0 license.</i>
Highlights
Коронавирусная инфекция 2019 года (COVID-19) — это вирусное заболевание, вызываемое новым коронавирусом тяжелого острого респираторного синдрома, SARS-CoV-2, который поражает легкие инфицированных лиц
The coronavirus disease 2019 (COVID-19) is a viral disease caused by a novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that affects the respiratory system of infected individuals
Numerous reports suggest that people with cancer can be at higher risk of severe illness and related deaths from COVID-19
Summary
COVID-19 И СОПУТСТВУЮЩАЯ ОНКОЛОГИЧЕСКАЯ ПАТОЛОГИЯ: ТЕРАПЕВТИЧЕСКИЕ ВОЗМОЖНОСТИ И СЛОЖНОСТИ. По состоянию на 29 сентября 2020 года более 235 стран, районов или территорий по всему миру сообщили в общей сложности о 33 441 919 подтвержденных случаях заболевания и о 1 003 497 подтвержденных смертях от COVID-19. Поэтому оказание онкологической помощи в условиях пандемии является сложной задачей и требует совместного междисциплинарного подхода для оптимального лечения онкологических больных в условиях стационара. В этом расширенном обзоре мы обсуждаем влияние пандемии COVID-19 на онкологических больных и оказание им медицинской помощи. Ключевые слова: COVID-19, коронавирусы, SARS-CoV-2, онкологические заболевания, воспаление, сопутствующая патология. Для цитирования: Патания А.С., Пратипати Ф., Абдул Б.А.А., и др. COVID-19 и сопутствующая онкологическая патология: терапевтические возможности и сложности // Juvenis scientia.
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