Abstract
Experiments on 33 Wistar rats were performed to test two interrelated hypotheses. Firstly, is the migration of fluorescein isothiocyanate (FITC) labeled endotoxin (Escherichia coli lipopolysaccharide, LPS) (5.0 μg in 5.0 μl of sterile water) via olfactory nerve into the brain after single submucous injection of LPS real? Secondly, in case such migration is feasible, is it possible to explain a number of clinical signs in patients infected with COVID-19 using the obtained facts? We are talking namely about the symptoms of damage to the terminals of olfactory and trigeminal nerves and corresponding brain neural networks due to COVID-19. Positive answers were received to both questions as a result of the experimental analysis.
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