Abstract
Corona virus pandemic outbreak also known as COVID-19 has created an imbalance in this world. Scientists have adopted the use of natural or alternative medicines which are consumed mostly as dietary supplements to boost the immune system as herbal remedies. India is famous for traditional medicinal formulations which includes ‘Trikadu’—a combination of three acrids, namely Zingiber officinale, Piper nigrum and Piper longum which have antioxidant properties that boost our immune system hence acting as a strong preventive measure. In this study, AutoDock 4.0 was used to study interaction between the phytocompounds of Trikadu with RNA-dependent polymerase protein and enveloped protein of the SARS-CoV-2 virus. Analysis of the results showed that coumarin, coumaperine and bisdemethoxycurcumin showed strong bonding interactions with both the proteins. We can conclude that Trikadu has the potential molecules; hence, it can be incorporated in the diet to boost the immune system as a preventive measure against the virus.Supplementary InformationThe online version contains supplementary material available at 10.1007/s12010-021-03793-5.
Highlights
The coronavirus (COVID-19) is an infectious disease-causing respiratory ailment affecting the lungs caused by a novel strain of virus called severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
The two proteins 6LXT which is a structure of post fusion core of 2019-nCoV S2 subunit whose resolution is 2.90 Å by X-ray diffraction and 6M71 which is a SARS-Cov-2 RNA-dependent RNA polymerase in complex with cofactors whose resolution is 2.90 Å by electron microscopy are docked with the phenolic phytocompounds of ginger, pepper and long pepper using the software Marvin view, AutoDock 4.0, BIOVIA Discovery studio and PyMol for simulation and visualization [17]
The protein structures were obtained from Protein Data Bank (PDB) and docked with 11 compounds of ginger, pepper and long pepper of the Trikadu mixture
Summary
The coronavirus (COVID-19) is an infectious disease-causing respiratory ailment affecting the lungs caused by a novel strain of virus called severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The virus has a main presenting symptom which is pneumonia and is suspected of having originated from a local seafood market whose source is an unknown animal most likely assumed to be bat for being responsible for the emergence and spread of the novel strain of the coronavirus [2]. We can avoid the immune weakening food and instead adding immune boosting food to our diet helps in providing strong defence mechanism to our body. This will avoid our body to be in a state of inflammation which further weakens our immune system. Trans fat and excessive carbohydrate-rich foods and by increasing daily consumption of plant-based food will increase antioxidants in our body and combat oxidative stress which in turn boost mitochondrial and cellular functions because spices are highly antioxidant and immune protective [6]
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