Abstract
European Journal of ImmunologyVolume 53, Issue 4 2370041 Cover PictureFree Access Cover Story: Eur. J. Immunol. 4'23 First published: 10 April 2023 https://doi.org/10.1002/eji.202370041AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat Graphical Abstract Our cover image features immunostaining of classical and non-classical MHC class I molecules on HPV6/11 induced respiratory papilloma epithelia. HLA-A, B, and C are absent on these epithelial cells but are expressed in the papilloma stroma. However, non-classical MHC class I molecules, HLA-E and -G, are strongly expressed on papilloma epithelial cells and stroma. The image are from Israr et al. This is the strategy used by HPV6/11 infection to block NK activation and reduce HPV6/11 peptide presentation to T-cells. The authors also show that papilloma cells express increased amounts of PGE2 that directly inhibits NK cell function by signaling through the NK cell PGE2 receptors EP2 and EP4. The original image was digitally modified for the cover. Volume53, Issue4April 20232370041 RelatedInformation
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