Abstract
European Journal of ImmunologyVolume 51, Issue 2 Cover PictureFree Access Cover story: Eur. J. Immunol. 2'21 First published: 05 February 2021 https://doi.org/10.1002/eji.202170020AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Abstract Our front cover features an immunohistochemical staining of mouse BRCC3 (mBRCC3) in liver sections, which is dramatically upregulated by intravenously with mBRCC3 constructs by hepatocyte gene transfer (HGT). The image is taken from Cheng et al. (pp. 296–310), where the authors report that BRCC36 maintains cellular STAT1 protein stability by forming a balanced complex with Smurf1 and USP13, thus promoting the innate antiviral immunity, revealing a delicate regulatory mechanism of STAT1 protein levels. Meanwhile, supplementing BRCC36 enhanced antiviral response of allo-HSCT mice by maintaining STAT1 stability. This study uncovers a critical role of BRCC36 in STAT1 protein stability and could provide potential strategies for enhancing clinical antiviral therapy. Volume51, Issue2February 2021 RelatedInformation
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