Abstract
The cover picture shows eight analgesic kalmane diterpenoids with a 5/8/5/5 tetracyclic carbon skeleton, isolated from the flowers of Rhododendron dauricum at Xiaoxing'anling, China. Rhodokalmanol A represents the first 5,8‐epoxykalmane diterpenoid and also the first kalm‐15(16)‐ene diterpenoid. Rhodokalmanols B—D are the first examples of kalm‐7(8)‐ene, kalm‐16(17)‐ene, and 8α‐methoxykalmane diterpenoids, respectively. All the isolated kalmane diterpenoids exhibited significant analgesic effects in the acetic acid−induced writhing test in mice. Among them, rhodokalmanol C and kalmanol expressed more potent analgesic activity than morphine at doses of 0.2 and 0.04 mg/kg. More details are discussed in the article by Yao et al. on page 1019—1027.image
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