Abstract

Pd‐catalyzed asymmetric allylic C—H functionalization has grown to be a general platform to access densely functionalized chiral molecules from easily available alkenes. In recent years, the adoption of asymmetric organo/palladium cooperative catalysis and building up a library of structurally tunable and bulky chiral phosphoramidite ligands have opened new avenues to create regio‐ and enantioselective Pd‐catalyzed allylic C—H functionalization reactions. Gong and coworkers describe their journey to the identification of asymmetric catalytic systems, mechanism of allylic C—H activation, control of stereo‐ and regioselectivity, and applications in asymmetric synthesis. More details are discussed in the article by Gong et al. on page 1841—1848.image

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