Abstract
The first enantiospecific total synthesis of (+)-pleuromutilin is reported. A SmI2-mediated cyclisation cascade allows access to the tricyclic core of the antibacterial natural product, constructing the five- and eight-membered rings in a single step, with high diastereocontrol. For more details, see the Full Paper by D. J. Procter et al. on page 6718 ff.
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