Abstract
The cover picture shows mRNA protected from miRNA-mediated silencing by a crosslink-forming oligonucleotide (CFO). The miRNA forms an RNA-induced silencing complex, and binds to its complementary sequence on target mRNAs. On p. 1427 ff., F. Nagatsugi et al. describe how the covalent linkage of the CFO to the miRNA biding region can definitely protect the mRNA from miRNA functions. This method can interfere with specific miRNA–mRNA interactions by recognizing the sequences unique to the 3′-UTR that are inherent in each mRNA.
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