Cover Picture: Structural Basis for Expansion of the Genetic Alphabet with an Artificial Nucleobase Pair (Angew. Chem. Int. Ed. 39/2017)

Abstract

Expansion of the genetic alphabet … … with hydrophobic artificial base pairs is a promising approach. In their Communication on page 12000 ff., A. Marx, I. Hirao, and co-workers present a high-resolution crystal structure of the dDs–dPx pair in the active site of a DNA polymerase. They show that the artificial base pair adopts a planar structure just like a natural nucleobase pair. Its varying size and shape, however, cause minor alterations near the active site. Expansion of the genetic alphabet … … with hydrophobic artificial base pairs is a promising approach. In their Communication on page 12000 ff., A. Marx, I. Hirao, and co-workers present a high-resolution crystal structure of the dDs–dPx pair in the active site of a DNA polymerase. They show that the artificial base pair adopts a planar structure just like a natural nucleobase pair. Its varying size and shape, however, cause minor alterations near the active site. Alzheimer′s Disease Chalcogen Bonding Fluoroalkyl ethers