Cover Picture: RhI‐Catalyzed Two‐Component [(5+2)+1] Cycloaddition Approach toward [5‐8‐5] Ring Systems (Chem. Asian J. 7/2010)

Abstract

Cycloaddition Reactions…︁ …︁ catalyzed by transition metal complexes have been of continuing interest to chemists owing to their efficiency in constructing complicated molecules from much simpler starting materials in atom- and step-economical fashions. It has been found that eight-membered carbocycles in many natural products are fused or bridge-fused with one or more five- or six-membered carbocycles. In their Communication on page 1555 ff., Z.-X. Yu et al. present [Rh(CO)2Cl]2-catalyzed two-component [(5+2)+1] cycloaddition of ene-vinylcyclopropanes that have various tether types and substituents with CO designed for one-pot synthesis of fused tricyclic cyclooctenones with atom and step economies.