Abstract
Polymorphs and cocrystals have crystal-engineering principles applied in pharmaceutical solids. A. Nangia and co-workers report two new conformational polymorphs of the antitumor drug temozolomide. X-ray diffraction on cocrystals of temozolomide and 4,4′-bipyridine-N,N′-dioxide showed that their 2:1 polymorphic structures (shown as yellow and red butterfly arrays) have different hydrogen-bonding and molecular-packing arrangements. The structural origins of synthon polymorphism in multicomponent cocrystals are remarkably similar to those of molecular crystals. For the details, turn to their Full Paper on page 1122 ff.
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