Abstract
A century of aryne chemistry has not dampened the interest in this class of reactive intermediates. The cover picture shows the structure of a calicheamicin–DNA complex, the “warhead” of which is a cyclic enediyne unit (highlighted). The biological activity of the enediyne cytostatics is based on the depicted Bergman cyclization of the enediyne to a didehydrobenzene biradical. More about these short‐lived species is given by Sander et al. on pp. 502 ff.
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