Cover Picture: MicroRNA‐Directed Intracellular Self‐Assembly of Chiral Nanorod Dimers (Angew. Chem. Int. Ed. 33/2018)

Abstract

The chiral self-assembly of plasmonic nanorod dimers in living cells, driven by complementary binding to a target miRNA sequence, and leading to specific plasmonic circular dichroism, surface-enhanced Raman scattering (SERS), and fluorescence signals is described in the Communication by H. Kuang, L. M. Liz-Marzán et al. on page 10544 ff. The method allows in situ imaging as well as highly sensitive and selective miRNA detection. It can also be extended to the study of biomolecular interactions, trafficking, and kinetics inside single living cells. The chiral self-assembly of plasmonic nanorod dimers in living cells, driven by complementary binding to a target miRNA sequence, and leading to specific plasmonic circular dichroism, surface-enhanced Raman scattering (SERS), and fluorescence signals is described in the Communication by H. Kuang, L. M. Liz-Marzán et al. on page 10544 ff. The method allows in situ imaging as well as highly sensitive and selective miRNA detection. It can also be extended to the study of biomolecular interactions, trafficking, and kinetics inside single living cells. Molecular Knots Kinetic Resolution DNA Nanotechnology