Abstract
Vitamin B12 (cobalamin) is an essential cofactor in all mammalian cells. Reduced cobalamins, cob(I)alamin (CoI) and cob(II)alamin (CoII), are intracellular precursors of the B12 cofactor forms. Both mammalian B12-dependent enzyme reactions are inactivated under oxidative stress conditions. Elevated levels of the potent reactive oxygen species peroxynitrite, formed by the diffusion-controlled reaction between .NO and O2.−, are associated with multiple chronic inflammatory diseases. The cover—designed by Frank Mueller—shows that peroxynitrite rapidly oxidizes cob(I)alamin and cob(II)alamin to inactive cob(III)alamins. More details are given in the Communication and Full Paper by R. Mukherjee and N. E. Brasch on pages 11723 ff. and 11805 ff., respectively.
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