Abstract
The cover picture shows the X‐ray structure of Sce VMA intein from Saccharomyces cerevisiae in the background. This intein has been extensively modified to overexpress proteins that have a C‐terminal thioester, which is the key component for the so‐called "Native Chemical Ligation Reaction" shown in the foreground. More details could be found in the article by S. Q. Yao et al. on p. 4664 ff.
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