Abstract
This month's colorful cover features a three‐dimensional plot of the fluorescence signal intensities on a reverse‐phase protein microarray. The plots show the signals generated from serially diluted cell lysates probed for β‐actin, which is used as a protein loading control. The image is taken from the article by Negm et al. (pp. 2096–2110) in which the authors examine the signaling intermediates in the cascading from a mutant TNF‐receptor (TNFR1). The authors found that both a human endothelial‐like cell line transfected with a mutant TNFR1 and primary human peripheral blood mononuclear cells from patients with TNFreceptor‐associated periodic syndrome (TRAPS) constitutively expressed a wide spectrum of signaling intermediates which are associated with a proinflammatory and antiapoptotic phenotype. This identification of this proinflammatory signalome may highlight potential target pathways for TRAPS intervention.
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