Abstract
This month's cover features a macro confocal macroscopy image of a mouse E10.5 embryo. It was stained with Hoechst 33342 (blue), and paternally inherited EGFP fluorescence (green), which are driven from the β‐actin promoter and enable to distinguish hematopoietic cells of maternal and embryonic origin. The image's background shows the expression profiles of different types of macrophages. These images were provided by Balounova et al. (pp. 1491–1502), who describe in this issue that TLRs are functionally expressed on yolk sac–derived macrophages during early mouse embryogenesis and contribute to inflammation‐mediated regulation of embryonic homeostasis via iron metabolism. Taken together, the results show that TLRs are involved in the maintenance of organismal homeostasis through the entire ontogenetic development, including early stages of embryogenesis.
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