Abstract
The cover of this issue is based on microscopy images of immature dendritic cells (DCs) stained with hematoxylin-and-eosin (H&E) provided by Chong et al. (pp. 1639–1651). In their article, Chong et al. investigate which cell types contribute to the differentiation of TNF/iNOS-producing dendritic cells (Tip-DCs), a subset of DCs that has been shown to arise during inflammation and to be an important mediator of immune defense. The authors provide evidence that CD8+ T cells can induce the rapid development of human monocytes into Tip-DCs that are capable of further driving Th1 responses by priming naive CD4+ T cells.
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