Abstract
The cover image shows immunohistological analysis of a spleen section from QMxB6 mice 96 hours after immunization with NP-Ficoll. IgD staining (brown) determines the B-cell follicles and NP-staining (blue) the antibody-producing cells; plasmablasts (dark blue regions) are present in the red pulp, and germinal centres (pale blue) can be seen in the follicles; the T zones (which lack B cells) remain unstained. The image is kindly provided by Jennifer Marshall and relates to the study Marshall et al. (pp. 3506–3512) in which it is shown that Ig class-switch recombination during extrafollicular responses occurs at the B blast rather than the plasmablast stage.
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