Abstract
The cover features a photograph of two neonatal nurse sharks. The image background shows two consecutive, pseudocolored, in situ hybridization‐stained sections from nurse shark spleen tissue. The tissue section image is taken from the article by Castro et al. (pp. 3061–3075) in which the authors describe antibody‐secreting cells in neonatal, juvenile, and adult nurse sharks, which do not express the “master regulator” transcription factor of plasma cells, Blimp‐1. Although Blimp‐1 was expressed in adult cells expressing monomeric IgM (7S), all Ig‐secreting cells in neonatal sharks were Blimp‐1‐negative, and Blimp‐1 was rarely detected in adult J‐chain‐positive, pentameric (19S) IgM‐secreting cells. These findings suggest that Blimp‐1 is not required to maintain memory B cells in the shark spleen but is required for terminating the B‐cell program following adaptive immunity.
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