Abstract
Sequence-specific modification (“writing”) and light-triggered removal (“erasing”) of DNA is reported for the first time in an enzymatic cascade. In their Research Article on page 480, Andrea Rentmeister and co-workers engineered SAM synthetases suitable for converting methionine analogs with photo-cleavable groups and show their compatibility with methyltransferases to provide DNA with a light-sensitive “cage”. Crystal structure analysis revealed how substitutions in the active site led to accommodation of the photo-cleavable group.
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