Abstract

The use of contrast agents (CAs) can enhance the accuracy and specificity of MR imaging to disease diagnosis, but their imaging signals are “always-on” regardless of whether they interact with target tissues or cells. In article number 20200141, Bingbo Zhang, Xiao Jin, Weitao Yang and their co-workers summarize recent progress on the design strategies and principles of activatable CAs, and analyze their advantages in biomedical applications compared to conventional MR CAs, to improve target-to-background signal ratio for better diagnosis.

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