Abstract
The cover picture illustrates the design process of a new 5‐LO inhibitor through molecular hybridization. The highlighted portions in each chemical structure represent the regions where structural fusion is applied, and the sparks depict the process of fusion. The target compound acts on the 5‐LO protein in mouse, relieving the ear edema. The drugs indicated by the prohibition sign in the bottom right corner are steroid‐based drug and a 5‐LO target drug called Zeiluton, both have toxicity issues. More details are available in the article by Young‐Chang Kim, Aizhan Abdildinova, Ye Jin Shin, Dong Kyun Han, Jong Yeon Hwang, Hyae Gyeong Cheon, Young‐Dae Gong. image
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