Abstract

The cover picture shows the catalytic reaction of enamine, which is generated from condensation between an amino catalyst and carbonyl derivatives with electron acceptors, such as aldehydes, imines, and ketones. To furnish products, the substrates have to climb the precipice to meet and touch the reaction center of the enamine intermediate. Strong hydrogen bonding effect of acidic Tf-amide functionality, which is described as lift, establishes a convenient route to access to Si-face of the top selectively, thereby affording enantioenriched products with enhanced reactivity and stereoselectivity. See the Personal Account by H.-J. Lee and K. Maruoka (DOI:10.1002/tcr.202200004).

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