Cover Picture: Construction of Enantioenriched 4,5,6,7‐Tetrahydrofuro[2,3‐b]pyridines through a Multicatalytic Sequence Merging Gold and Amine Catalysis (Adv. Synth. Catal. 19/2021)

Abstract

The inside cover picture, designed by Fabrice Goursaud, holder of a PhD in organic chemistry and recently graduated from art school, illustrates the stereoselective synthesis of tetrahydro[2,3-b]pyridine frameworks via one-pot metal-organo relay catalysis. The strategy, which involves a gold-catalyzed cycloisomerization and a chiral amine mediated cycloaddition reaction, provides the targeted molecules in yields ranging from 27 to 90% and high levels of stereoselectivity (de>95%, 93–99% ee). Details can be found in the Communication by Manon Genet, Abdelilah Takfaoui, Jérôme Marrot, Christine Greck and Xavier Moreau. (M. Genet, A. Takfaoui, J. Marrot, C. Greck, X. Moreau, Adv. Synth. Catal. 2021, 363, 4516–4520; DOI: 10.1002/adsc.202100756).