Cover Picture: Binding of a Designed Anti-Cancer Drug to the Central Cavity of an RNA Three-Way Junction (Angew. Chem. Int. Ed. 44/2013)

Abstract

Recognition and stabilization of an RNA three-way junction by a supramolecular di-iron(II) cylindrical complex is described by R. K. O. Sigel, B. Spingler, M. J. Hannon, E. Freisinger et al. in their Communication on page 11513 ff. This potential anti-cancer metal-based drug fits perfectly into the central RNA core and stabilizes this architecture in the solid state as well as under native gel conditions. (Cover picture: Joachim Schnabl.)