Abstract
The cover picture shows an imaging study of a cytotoxic small molecule AA005, which is able to recognize and enter human cancer cells selectively. Fluorescent labeling of AA005 was successfully accomplished by a bioactivity assessment‐aided protocol after examining a number of potential derivative positions in parallel. AA005‐flu was found to exhibit similar cell selectivity to its parent molecule AA005. Fluorescent images of AA005‐flu show a significant difference in drug distribution between cancerous and normal cells, with accumulation of AA005‐flu occurring in the mitochondria of cancers cells. For more information, see the article by Z.‐J. Yao et al. on p. 172 ff.
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