Cover Photograph: Hippo signaling controls cell fates in preimplantation mouse embryos. Slightly different mechanisms operate in regulation of Hippo signaling between 16‐cell stage and early blastocyst stage with more than 32 cells. Panels show the confocal images of the 16‐cell (left panel) and early blastocyst (right panel) stage embryos stained with phosphorylated Ezrin/Radixin/Moesin (magenta), a marker for apical domain and

Abstract

Development, Growth & DifferentiationVolume 57, Issue 8 p. i-i Cover ImageFree Access Cover Photograph: Hippo signaling controls cell fates in preimplantation mouse embryos. Slightly different mechanisms operate in regulation of Hippo signaling between 16-cell stage and early blastocyst stage with more than 32 cells. Panels show the confocal images of the 16-cell (left panel) and early blastocyst (right panel) stage embryos stained with phosphorylated Ezrin/Radixin/Moesin (magenta), a marker for apical domain and cell polarization, and the Hippo pathway coactivator Yap (green). In the early blastocysts, cell position regulates cell polarization through the Par-aPKC system, and cell polarity controls Hippo signaling. Therefore, all the outer cells are polarized and exhibit nuclear Yap. In contrast, at the 16-cell stage, Par-aPKC-independent mechanism and asymmetric cell division are also involved in regulation of cell polarization. Therefore, some outer cells are apolar and show cytoplasmic Yap. First published: 17 October 2015 https://doi.org/10.1111/dgd.12175AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat No abstract is available for this article. Volume57, Issue8October 2015Pages i-i RelatedInformation