Abstract
Novel coumarinyl–1,3–thiazin–2–thione derivatives were efficiently synthesized via multi–component reaction of 3 –chloro–3–(2–oxo–2H–chromen–3–yl)acrylaldehyde,carbon disulfide and amines. All the derivatives were screened for their anti‐proliferative activity against several cancer cell lines. The molecular docking study and ADME profile were also performed to explore the binding interaction of these coumarinyl–1,3–thiazin–2–thione analogues with Hsp100 proteins. More details will be discussed by Dr. Santhosh Penta and his co‐workers on page 811–821 in this issue. image
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