Cover Image

Abstract

IUBMB LifeVolume 75, Issue 6 COVER IMAGEFree Access Cover Image First published: 02 May 2023 https://doi.org/10.1002/iub.2731AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Graphical Abstract On the Cover: Examples of the roles of proteases in prostate cancer development and progression. A simplified scheme of the roles of the major proteases discussed in this review is illustrated. The schematic representation of tumor growth and early steps of metastatic dissemination, shown in the center panel, include: 1) Proliferative and EMT signaling (interaction of cancer and stromal cells and inflammatory responses); 2) Cancer cell migration and invasion, involving ECM remodeling and signaling; 3) Stimulation of (lymph)angiogenesis and intravasation of invasive cancer cells, involving ECM remodeling, degradation of anti-angiogenic factors, production of angiogenic peptides and growth-factor activation; 4) Stromal cells, including cancer-associated fibroblasts (CAFs), are also involved in tumorigenic processes; 5) A small fraction of circulating tumor cells (CTCs) survive and eventually form distant metastases. These processes often involve autocrine-paracrine loops in the prostate cancer microenvironment, which due to simplicity have been omitted here by Koistinen et al.; Article first published: 04 Jan 2023; https://doi.org/10.1002/iub.2700 Volume75, Issue6June 2023 RelatedInformation