Abstract
The total chemical synthesis of proteins has played a significant role in both fundamental research and therapeutic application, primarily due to its full and flexible control on the protein composition, allowing generation of biologically inaccessible protein forms. Utilizing a o‐aminoaniline linker and taking full advantages of solid phase ligation to minimize tedious purification steps, Hong et al. report a new convergent hybrid phase ligation strategy to enable efficient and convenient synthesis of challenging proteins from many synthetical accessible fragments with only one single purification. The new strategy demonstrates its feasibility in preparation of two histone proteins, CENP‐A and H1.2 with various PTMs and should find more applications in other proteins. image
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