Abstract
The development of DNA-compatible reactions is central to advance DNA-encoded library technology. Amphiphilic block copolymer micelles functionalized with sulfonic acid moieties assemble in water to micelles and localize the catalyst in them. DNA-aldehyde conjugates were reacted to target heterocycles by micelle-promoted Povarov- and Biginelli-reaction with minimal DNA damage. Strikingly, DNA-conjugates accumulated effectively in the micellar compartments as a prerequisite for compound synthesis. More information can be found in the Full Paper by R. Weberskirch, A. Brunschweiger, et al. (DOI: 10.1002/chem.202100980).
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