Abstract

A new size-expanded fluorescent T-mimic deoxyribonucleoside is reported, based on a dioxoloquinazoline core, named as dioxT. dioxT showed comparable biophysical properties and displayed notable photophysical characteristics including an excellent quantum yield (0.36) in water as a fluorescent thymine surrogate. Interestingly, when the dioxT-containing strand was hybridized with a complementary strand, the duplex exhibited higher fluorescence than a single strand. dioxT can be used for a broad range of applications in chemical biology. More information can be found in the Full Paper by S. Park, H. Sugiyama, et al. on page 9913.

Full Text
Published version (Free)

Talk to us

Join us for a 30 min session where you can share your feedback and ask us any queries you have

Schedule a call