Abstract
A new size-expanded fluorescent T-mimic deoxyribonucleoside is reported, based on a dioxoloquinazoline core, named as dioxT. dioxT showed comparable biophysical properties and displayed notable photophysical characteristics including an excellent quantum yield (0.36) in water as a fluorescent thymine surrogate. Interestingly, when the dioxT-containing strand was hybridized with a complementary strand, the duplex exhibited higher fluorescence than a single strand. dioxT can be used for a broad range of applications in chemical biology. More information can be found in the Full Paper by S. Park, H. Sugiyama, et al. on page 9913.
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