Abstract
Nucleotide analogues lacking the 3’-hydroxyl group have antiviral activity. The image illustrates the finding that a thermostable radical-SAM enzyme catalyses transformation of natural and unnatural nucleotides to their 3’-deoxy analogues by a mechanism requiring a proton-coupled electron transfer step from a tyrosine residue. A nucleotide analogue synthesised by the enzyme is known to have broad-spectrum antiviral activity in humans. The findings suggest a new enzymatic route for green biosynthesis of antiviral nucleotide analogues. More information can be found in the full paper by K. Honarmand Ebrahimi et al.
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