Abstract

RuII polypyridyl complexes are promising candidates for application in the field of photodynamic therapy, thanks to their rich chemical physical repertoire. This work reports on two novel RuII and RuII/CuII mixed polypyridyl compounds which feature great cellular uptakes and can generate highly cytotoxic species when light-activated. The study highlights the key role of the Fenton active CuII center within the macrocycle residue of such compounds that would play a synergistic action with light activation in the formation of powerful Reactive Oxygen Species. More information can be found in the Full Paper by L. Conti, C. Giorgi, et al. on page 10606.

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