Cover Feature: Exploring the Flexibility of the Glycopeptide Antibiotic Crosslinking Cascade for Extended Peptide Backbones (ChemBioChem 6/2023)

Abstract

Glycopeptide antibiotic (GPA) crosslinking is performed by cytochrome P450 (Oxy) enzymes and is essential for antibiotic activity. Here, we symbolise the process by which we screen for Oxy activity toward altered peptide substrates, which revealed that these enzymes are tolerant of extension at the N-termini of their peptide substrates. More information can be found in the Research Article by J. Tailhades, M. J. Cryle et al.