Cover Feature: Engineered Cyclotides with Potent Broad in Vitro and in Vivo Antimicrobial Activity (Chem. Eur. J. 49/2021)

Abstract

ESKAPE kit: A novel engineered cyclotide has effective broad-spectrum antibacterial activity against several ESKAPE bacterial clinical isolates. The most active antibacterial cyclotide showed high in vivo efficacy against Pseudomonas aeruginosa, a human pathogen known to produce chronic lung infection in humans. These findings suggest the possibility of designing novel therapeutics based on the cyclotide scaffold. More information can be found in the Full Paper by J. A. Camarero et al. (DOI: 10.1002/chem.202101438).