Cover Feature: Diversity‐Oriented Synthesis of [2.2]Paracyclophane‐derived Fused Imidazo[1,2‐a]heterocycles by Groebke‐Blackburn‐Bienaymé Reaction: Accessing Cyclophanyl Imidazole Ligands Library (Chem. Eur. J. 3/2022)

Abstract

The Groebke–Blackburn–Bienaymé three-component reaction (GBB-3CR) has contributed enormously to the progress of organic synthesis, medicinal chemistry, and materials science. Diversity-oriented synthesis of skeletally diverse cyclophanyl-derived fused imidazo[1,2-a]heterocycles by one-pot GBB-3CR involving formyl-cyclophane components in combination with various aliphatic and aromatic isocyanides and heteroaromatic amidines gives a library of versatile cyclophanyl imidazoles ligands. These can be readily transformed to prepare N,C palladacycles by regioselective ortho-palladation. More information can be found in the Full Paper by S. Bräse et al. (DOI: 10.1002/chem.202103511).