Abstract

Probing the hydroxyproline residue (Hyp) of alpha-amanitin, this structural activity relationship study investigates the conformation and H-bonding network of the first Hyp-analogs of the extremely toxic, RNA polymerase II inhibiting, fungal octapeptide for its potential as a warhead in antibody-drug conjugates. More information can be found in the Full Paper by A. Pahl, D. M. Perrin, et al. (DOI: 10.1002/chem.202101373).

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