Abstract
Carbon monoxide (CO) is an endogenous signaling molecule with a remarkable therapeutic potential hindered by its inherent toxicity. The cross-breeding of a CO-releasing flavonol moiety with a cyanine dye enabled access to the family of CO-releasing molecules activatable upon irradiation with near-infrared light up to 820 nm. These hybrids liberate two molecules of CO with efficiencies surpassing those of the state-of-the-art systems by two orders of magnitude. The biocompatibility and applicability of this system were showcased both in vitro and in vivo. The cover image was created by Lenka Štacková, Peter Štacko, and Orazio Angelo Arcidiacono. More information can be found in the Full Paper by P. Štacko, P. Klán, et al. on page 13184.
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