Cover Feature: An Improved Stereocontrolled Access Route to Piperidine or Azepane β‐Amino Esters and Azabicyclic β‐ and γ‐Lactams; Synthesis of Novel Functionalized Azaheterocyles (28/2021)

Abstract

The Cover Feature shows the structure of some fluorine-containing azaheterocycles (amino esters, lactams) and the Globe (Terra) which is continuously exposed to pollution and overload with various substances. A simple and efficient chemical procedure affords versatile, functionalized fluorine-containing azaheterocycles, which have been synthetized with stereocontrol through oxidative ring opening across ozonolysis followed by ring closure with double reductive amination. More information can be found in the Full Paper by L. Kiss et al.