Abstract
The inherent competition between the bimolecular nucleophilic substitution (SN2) and base-induced elimination (E2) reactions is depicted in the cover image. This work reports a physically sound and intuitive model to elucidate why strong Lewis bases act as protophiles (E2), while weak Lewis bases behave as nucleophiles (SN2). The general concepts of “characteristic distortivity” and “transition state acidity” are developed, which will serve as the cornerstone for the rational design of novel reactions. More information can be found in the Full Paper by T. A. Hamlin, F. M. Bickelhaupt, et al. on page 15538.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
